Political Wrinkles  

Go Back   Political Wrinkles > General Discussion > Health, Wellness, Sex and Body
Register FAQDonate PW Store PW Trivia Members List Calendar Search Today's Posts Mark Forums Read

Health, Wellness, Sex and Body Discuss Can Ticks Make You Allergic to Red Meat? at the General Discussion; A few years ago, Dr. Thomas Platts-Mills, the director of the University of Virginia School of Medicine’s allergy division, conducted ...

Reply
 
Share LinkBack Thread Tools Display Modes
  #1 (permalink)  
Old 03-28-2015, 03:48 PM
foundit66's Avatar
Moderator
 
Join Date: Oct 2007
Location: California
Gender: Male
Posts: 24,368
Thanks: 9,650
Thanked 14,674 Times in 8,868 Posts
Post Can Ticks Make You Allergic to Red Meat?

Quote:
A few years ago, Dr. Thomas Platts-Mills, the director of the University of Virginia School of Medicine’s allergy division, conducted an informal experiment. He spent five hours hiking and bushwhacking in the Blue Ridge Mountains, near his home in Charlottesville, Virginia. Afterward, his feet itched. When he pulled off his shoes and socks, the skin around his ankles was rough and pimpled. He suspected that he had stumbled into a nest of lone-star ticks, the most abundant species of tick in the southeastern United States, named for a distinctive, Texas-shaped white splotch that forms on the backs of adult females. “There were ticks all over the house,” he told me. “Luckily, my wife was not home.”

Adult lone-star ticks can carry the pathogens that cause several diseases: Rocky Mountain spotted fever; Southern tick-assocated rash illness, which manifests in Lyme-like symptoms; and ehrlichiosis, a cluster of related bacterial illnesses. (Michael Specter wrote about tick-borne disease in the magazine last year.) But Platts-Mills, who is the only allergist in the Royal Society, embarked on the hike because he believed that the ticks could cause another ailment: an allergy to red meat.



Platts-Mills first heard about allergic reactions to meat over twenty years ago, when a handful of patients at his practice claimed that a few hours after eating meat at dinner they woke up slicked in sweat, their throats closing, with blotchy rashes splashed across their torsos. Platts-Mills told them to avoid beef, pork, lamb, or venison, but suspected that the allergy was psychosomatic, and gave it little further thought.

Then, in the spring of 2000, one of Platts-Mills’s colleagues, Roger B. Cohen, now at the University of Pennsylvania, came to him with a problem. Cohen had been working on clinical trials for cetuximab, a drug therapy that slows the growth of certain cancer cells. Despite its promise in treating cancer, cetuximab occasionally caused allergic reactions in patients, comparable to bad bee stings. Platts-Mills worked to unravel the root cause of the allergy, but it eluded him.

In 2004, cetuximab received F.D.A. approval for treating colorectal cancer. Soon afterward, Bert O’Neil, then an oncologist in Chapel Hill, North Carolina, reported that nearly a quarter of his patients suffered from itching, swelling, and a dangerous drop in blood pressure when they took the drug. Curiously, however, the reactions were regional: they were about ten times as likely to occur in the southeast as elsewhere in the country; a patient in Tennessee died. (O’Neil says his team’s allegation seemed so unlikely that an oncologist in New York “thought we were lying or crazy.”)

Working with Bristol-Myers Squibb, cetuximab’s distributor, and numerous colleagues, Platts-Mills returned to his study of the drug, and began comparing blood drawn from patients with allergic reactions to control samples from California, Boston, and Tennessee. In a study published in the New England Journal of Medicine, he identified the cause of the symptoms: the allergic patients had preëxisting antibodies to alpha-gal, a sugar found in non-primate mammals, that cetuximab, derived from genetically modified mice, contains.

Mystery solved, mostly. What doctors lacked, however, was a satisfying explanation for what caused the antibodies, known as Immunoglobulin E, or IgE, that made patients so sensitive to alpha-gal; suspects included mice and tapeworms, an insidious mold creeping across the South, or a contagion that seemed to coincide with summer heat and humidity. (The packaging for cetuximab warns about the possibility of severe allergic reactions, and a spokeswoman for Bristol Myers-Squibb says that the reason for hypersensitivity to the drug is still unknown.) As Platts-Mills pondered a list of possible parasites, a technician in his lab, Jacob Hosen, noticed that states with a large number of reactions to cetuximab neatly overlapped with the range of Rocky Mountain spotted fever. As Platts-Mills began to suspect that ticks were connected to the alpha-gal sensitivity, a forty-three-year-old hunter came into his clinic claiming that he had suffered from three separate severe allergic reactions to eating beef, which contains alpha-gal. When Platts-Mills asked about ticks, the hunter revealed that his feet were covered with bites. Platts-Mills began to screen patients who reported tick bites or red-meat allergies for IgE.

Shortly afterward, Platts-Mills went on his own tick-infested journey through the woods, half-attempting to prove his theory. When he ran samples of his own blood, he found that his IgE antibody count had spiked. Later that year, he ate three lamb chops for dinner. Several hours later, around 1 A.M., he woke up covered in hives.
Can Ticks Make You Allergic to Red Meat? - The New Yorker

Holy crap!
__________________
“Labor is prior to, and independent of, capital. Capital is only the fruit of labor, and could never have existed if labor had not first existed. Labor is the superior of capital, and deserves much the higher consideration.”
~Abraham Lincoln
Reply With Quote
The Following 3 Users Say Thank You to foundit66 For This Useful Post:
  #2 (permalink)  
Old 03-28-2015, 05:04 PM
saltwn's Avatar
PW Enlightenment
 
Join Date: Oct 2007
Location: Esto perpetua
Posts: 71,859
Thanks: 52,259
Thanked 24,892 Times in 17,618 Posts
Send a message via Yahoo to saltwn
Default Re: Can Ticks Make You Allergic to Red Meat?

i dont understand the genetically modified mice thing. do the ticks first bite the mice?
__________________
Let us never forget that government is ourselves and not an alien power over us. The ultimate rulers of our democracy are not a President and senators and congressmen and government officials, but the voters of this country. ~Franklin D. Roosevelt
Reply With Quote
The Following User Says Thank You to saltwn For This Useful Post:
  #3 (permalink)  
Old 09-12-2017, 12:03 AM
Master
 
Join Date: Dec 2011
Location: Okolona
Gender: Male
Posts: 1,575
Thanks: 1,181
Thanked 446 Times in 378 Posts
Red face Re: Can Ticks Make You Allergic to Red Meat?

Deadly tick gets loose...

Officials announcing outbreak of deadly disease spread by ticks in Japan bring an insect to press conference... and it ESCAPES
8 September 2017 | A news conference descended into chaos after a deadly insect disappeared; Meeting had been called to raise awareness about Thrombocytopenia syndrome; The Japanese governor was left red-faced and forced to issue a public apology
Quote:
A Japanese news conference which aimed to raise awareness of a tick-borne disease ended in disaster when a live tick disappeared. The governor of Miyazaki prefectural was left red-faced when he was forced to apologise on Tuesday, a day after the debacle. Monday's conference had been organised by the Miyazaki prefectural government to raise awareness about the tick-borne disease Thrombocytopenia syndrome (SFTS), after a number of residents in the district had fallen ill with it.


Moments before the deadly tick disappears: An official attempts to pick up the live insect with a pair of tweezers

SFTS can be deadly, with symptoms including fever, a reduction in the cells that clot blood to prevent people from bleeding out, nausea and vomiting, and a decline in white blood cells which help fight off infection in the body. Despite prefectural government officials carrying out a desperate search for the insect - even roping in reporters to help them - the little critter could not be found. The room was later sprayed with insecticide, according to officials. 'We should have been more careful about safety management as the prefecture is in a position to alert its people,' said Miyazaki governor Shunji Kono. A live tick and a dead one had been brought along to the event for the press to photograph but when an official attempted to pick up the live one with tweezers it disappeared.


One live and one dead tick were brought into the press conference so the media could take photographs and help raise awareness about Thrombocytopenia syndrome

Last month, the Ehime prefectural government announced the death of a farmer in his 60s from the city of Shikokuchuo after he fell ill with spotted fever as a result of a tick bite. SFTS is a relatively new infectious disease which has so far been found in China, Korea and Japan. Symptoms usually develop within two weeks of the initial infection. According to Japanese media, the first reported case of SFTS contracted from a tick bite was in 2013, but the syndrome was first discovered in China in 2009. The virus is said to have high fatality rates of up to 30 per cent and people aged over 50 are more at risk. Japan's health ministry has previously issued a warning for people in contact with animals in poor physical condition to be careful.

Deadly tick escapes during Miyazaki press conference | Daily Mail Online
__________________
The water's always turbulent where two great rivers meet.
Reply With Quote
Reply

Tags
allergic, can, make, meat, red, ticks, you

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

Forum Jump


All times are GMT -5. The time now is 11:45 AM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2017, vBulletin Solutions, Inc.

Content Relevant URLs by vBSEO 3.2.0