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Health, Wellness, Sex and Body Discuss Blood pressure drugs tied to breast cancer risk at the General Discussion; I always wonder why is it that even with cancer both women & men are studied differently? More directly is ...

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Old 08-08-2013, 03:21 PM
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Default Blood pressure drugs tied to breast cancer risk

I always wonder why is it that even with cancer both women & men are studied differently?
More directly is that I have higher than normal blood pressure I twice a day take one pill spilt into half to maintain a normal pressure. And for the most part it does work out well, unless there is a good reason for me to blow off some sream.

Which I can go from normal to 100 mph in just a few seconds... I do thank our Lord, for not letting me do this as much as I did while I was younger... In fact I can maintain a lot of control even under pressure in a few cases.

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Blood pressure drugs tied to breast cancer risk

Genevra PittmanAugust 5, 2013

NEW YORK (Reuters Health) - Women taking a common type of blood pressure drug for a decade or more are over twice as likely to be diagnosed with breast cancer as those not on the medication, a new study suggests.

Researchers said the findings are not definitive enough to drive changes in how so-called calcium channel blockers are prescribed, and would first have to be replicated in other groups of women.

"We don't really think these results should change any current clinical practice," Dr. Christopher Li, who led the study at the Fred Hutchinson Cancer Research Center in Seattle, said.

"The most important thing is to have people manage their hypertension the best they can," he told Reuters Health, adding that people with high blood pressure often have to try multiple drugs at different doses to find the treatment regimen that works best for them.

Close to 98 million prescriptions were filled for calcium channel blockers in the U.S. in 2010, the researchers said - and once prescribed, people often take them for the rest of their lives.

Those drugs include amlodipine, marketed as Norvasc, and nicardipine, marketed as Cardene, among many others.

Li and his colleagues looked specifically at the two most common types of invasive breast cancer, ductal and lobular - distinguished by whether the cancer starts in a milk duct or milk-producing gland.

Their study included 905 women age 55 to 74 who were diagnosed with ductal breast cancer between 2000 and 2008, 1,055 women diagnosed with lobular breast cancer and 891 women without cancer who served as a comparison group.

Close to 40 percent of participants in each group took medication for high blood pressure.

Current users of calcium channel blockers included 85 women with ductal breast cancer, 91 with lobular breast cancer and 70 without cancer.

Twenty-five women with ductal breast cancer and 26 with lobular breast cancer had been using the drugs for 10 years or longer, compared to 11 cancer-free women. That worked out to a 2.4- to 2.6-fold higher risk of cancer with long-term use of calcium channel blockers.

However, no other hypertension drugs, including diuretics and beta blockers, were tied to breast cancer, the researchers wrote Monday in JAMA Internal Medicine.

Li said it's possible that calcium channel blockers interfere with a natural self-destruct mechanism in sick cells.

"But that's very speculative," he added.

The study raises a hypothesis for researchers to test in the future, said Patricia Coogan, an epidemiologist from Boston University who wrote a commentary published with the new report. The drugs have now been around long enough, she added, that plenty of women have taken them for a decade or more.

"If other large studies start finding the same thing, then a serious discussion needs to take place," Coogan told Reuters Health.

But for now, she agreed with Li that women who get their blood pressure under control using calcium channel blockers shouldn't stop taking them, or be too concerned about any extra risk of breast cancer.

"A far more immediate health risk is uncontrolled high blood pressure, and that is the most important thing to have in mind," Coogan said.

SOURCE: JAMA Network | JAMA Internal Medicine | Online First JAMA Internal Medicine, online August 5, 2013.
Blood pressure drugs tied to breast cancer risk
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Old 08-08-2013, 03:35 PM
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Default Re: Blood pressure drugs tied to breast cancer risk

That is the exact same cancer I had, ductal cancer, in the spring of last year, with a resulting mastectomy. It was found on a routine 3 yearly mammogram that all women over a certain age have here as standard checks.

It could have happened even without being on anti-hypertensives which I had been on for 10 years.

I am off the tablets now as my potassium was high in my blood and anti-hypertensives can cause high readings. However my blood pressure has been normal since last autumn without anti-hypertensives, so I needed them at the time but not now. The less meds I take the better in my opinion.

I would like to think that had I not needed them I would have had stable BP, but the risks of not taking BP meds are also high.

The danger is that people will stop taking anti-hypertensives thinking they can halt BC.

Interesting article, thanks.
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Old 08-08-2013, 06:15 PM
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Default Re: Blood pressure drugs tied to breast cancer risk

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That is the exact same cancer I had, ductal cancer, in the spring of last year, with a resulting mastectomy. It was found on a routine 3 yearly mammogram that all women over a certain age have here as standard checks.

It could have happened even without being on anti-hypertensives which I had been on for 10 years.

I am off the tablets now as my potassium was high in my blood and anti-hypertensives can cause high readings. However my blood pressure has been normal since last autumn without anti-hypertensives, so I needed them at the time but not now. The less meds I take the better in my opinion.

I would like to think that had I not needed them I would have had stable BP, but the risks of not taking BP meds are also high.

The danger is that people will stop taking anti-hypertensives thinking they can halt BC.



Interesting article, thanks.
Your welcome Pretty Flamingo and my for sharing & informing some, with more data.

I want to have talks with my doctor about dropping certain meds from the many I do take.

And the VA system make a big point on Dang it I deleted the artical a few days ago. It wa sabout Cholesterol Readings and just what is & isn't important pertaining to each reading.

Going so far to say {and they had test results to back it up} having a higer than what is now normal cholesterol reading isn't harmful as once was the case...

I missed talking to my doctor about that to. Shingles is another case I want more data on.
As not any living member of my family can recall if I or any of my brothers ever had Chicken Pox.
Can one still take this shot. except it might then cause shingles I have found out by use of the internet web health care sites.

See the VA has this internet system where what I do in person or by the telephone {wasting time while waiting etc.} can be done over the inter net.

Yet I got bad info on it and important info wasn't shared with me. So I have spent a month trying to solve this...

Now I am thinking I might have to delete my VA account and start all over if that is even possible to do & get a new account.

So more time needed to visit the VA helth care guy for this project.
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Old 10-28-2013, 11:56 AM
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Default Re: Blood pressure drugs tied to breast cancer risk

Then what would be an good alternative to drugs in controlling high blood pressure without risking getting breast cancer? {Link Removed}

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Old 10-28-2013, 04:05 PM
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Then what would be an good alternative to drugs in controlling high blood pressure without risking getting breast cancer? Cancer Defect
Well the first thing I se is STOP SMOKING, which for me isn't a choice... I have lived a real decent life so what lies ahead doesn't scare me at all.

If I were in say my mid twenties and never joined the US Army I would not be smoking but would be in fear of what some foolish nation will do sometime in our future to craete one very large world wide problem....

Just wait and see, as it will happen...
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Old 10-28-2013, 04:07 PM
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Default Re: Blood pressure drugs tied to breast cancer risk

Quote:
Originally Posted by mlurp View Post
I always wonder why is it that even with cancer both women & men are studied differently?
More directly is that I have higher than normal blood pressure I twice a day take one pill spilt into half to maintain a normal pressure. And for the most part it does work out well, unless there is a good reason for me to blow off some sream.

Which I can go from normal to 100 mph in just a few seconds... I do thank our Lord, for not letting me do this as much as I did while I was younger... In fact I can maintain a lot of control even under pressure in a few cases.


Blood pressure drugs tied to breast cancer risk
also not walking tied to risk
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Old 10-28-2013, 04:09 PM
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Default Re: Blood pressure drugs tied to breast cancer risk

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Then what would be an good alternative to drugs in controlling high blood pressure without risking getting breast cancer? Cancer Defect
yes and where do I go for withdrawal and therapy as this is a very addicting drug?
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Old 10-28-2013, 04:32 PM
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also not walking tied to risk
I have a mountain bike and a standing bike to ride, walking is so slow
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